Were you thinking of getting a mesotherapy treatment, but you are asking yourself this one question – does mesotherapy hurt? Maybe fear of the pain stops you from getting it at all? There is nothing to be afraid of. Generally, mesotherapy doesn’t hurt. Most patients report that mesotherapy procedure is not painful. It might rather cause discomfort, not pain. And even that can be minimalized by using a very fine needle or applying a topical anesthetic. Compared to for example alternative of liposuction, it is way less painful. If you have any questions or concerns associated with the treatment, discuss them with your practitioner prior to the procedure.